I am approaching the world as a realist. (For a background of my epistemology please see: My Evidentialist Epistemology). What I mean by this is that the external reality is how it appears to be to an observer making an epistemic inquiry, the measurements from science accurately depicts reality. This is in contrast to instrumentalism, which suggests that our inquiry of the world, scientifically, do not accurately depict reality but as useful fictions. An instrumentalist is more concerned about data fitting theories and predictions than with an accurate depiction of reality.
For the realist-evidentialist, the ontology of the world determines one’s epistemology. They congruently correspond. It is important to note the order of entailment. Antecedently, reality determines our epistemology. It would be illicit to reverse the term order and as Roy Bhaskar notes, it would be the epistemic fallacy. I am not advocating a naïve realism where reality acts on the human mind without personal inquiry nor am I advocating postmodern anti-realism where one can construct whatever type of reality is desired. I am advocating a form of critical realism.
Lorenzo Valla’s (1406-1457) interrogative (interrogatio) form of inquiry. Valla’s mode of inquiry yield results that are entirely new, giving rise to knowledge that cannot be derived by an inferential process from what was already known. Valla transitioned from not only using this method for historical knowledge but also applied it as “logic for scientific discovery.”