There isn’t a straight line of demarcation between science and pseudoscience (PS), which is universally applicable in all fields categorized as scientific.  A general guide for demarcating between the two is that the theory should have observable evidence, provides predictions, uses non-controversial reasoning, and is repeatable.  These are simply guidelines and do not necessarily count as criteria for disqualifying a theory if all aren’t met because some are simply untenable depending on the field in which they are applied.  Falsification is not necessary for a scientific theory but it does help substantiate the theory as a robust scientific theory.

When considering the criterion of observable evidence I make the distinction between observation and what is empirical.  Something may be observed and qualify as evidence even though it’s not related to material causes.  This is where the distinction between Duhemian science and Augustinian science must be made. I would deny the use of Duhemian science.  This method, or philosophy, has a goal of stripping science from all metaphysical imports.  Augustinian science is open to metaphysical presuppositions with science.  In the mid 1800’s William Whewell was the first to restrict science to only mean natural science.  Pierre Duhem followed this idea and constructed a methodology, which barred explanations to material causes.  For instance, agent causation is completely compatible with Augustinian science but is prohibited as a scientific explanation in Duhemian science.  Agent causation is something that can be observed but isn’t necessarily reductionistic in the material sense as with material causation because agent causation has metaphysical import.