Definition: A mode of inquiry in which questions yield results that are entirely new, giving rise to knowledge that cannot be derived by an inferential process from what was already known.
More about the term: Lorenzo Valla (1406-1457) developed the interrogative (interrogatio) rather than the problematic (quaestio) form of inquiry. This method was similar to the works of Stoic lawyers and educators like Cicero and Quintilian; that is, questioning witnesses, investigating documents and states of affairs without any prior conception of what the truth might be. Valla transitioned from not only using this method for historical knowledge but also applied it as “logic for scientific discovery.”
Valla’s logic for scientific discovery was the art of finding out things rather than merely the art of drawing distinctions and connecting them together. He called for an active inquiry (activa inquisitio). John Calvin (1509-1564) applied this method to the interpretation of Scripture and thus became the father of modern biblical exegesis and interpretation. Francis Bacon (1561-1626) applied it to the interpretation of the books of nature, as well as to the books of God, and became the father of modern empirical science.
 Thomas F. Torrance, “Einstein and Scientific Theology,” Religious Studies 8 no. 3 (1972): 236-237.
 Valla served in conjunction with Andrea Alciati (1492-1550) as Calvin’s primary influence for his biblical interpretation.
 Torrance, 237.